论文部分内容阅读
最近Ｘｅｎｏｖａ公司宣布它的Ｐ 糖蛋白 (Ｐ ｇｐ)泵抑制剂ＸＲ9576对多药抗性癌症有阳性结果。Ｐ ｇｐ等蛋白泵能引起一些药物细胞外流 ,从而使药物失效。在癌症病人中 ,Ｐ ｇｐ过度表达是抗药性的最主要表现形式。化疗药物中加入Ｐ ｇｐ抑制剂可保证药物在细胞中并起效达 2
Xenova recently announced that its P-glycoprotein (P gp) pump inhibitor XR9576 is positive for multidrug resistant cancers. P gp protein pump can cause some drug extracellular flow, so that drug failure. In cancer patients, Pgp overexpression is the most important manifestation of drug resistance. Chemotherapy drugs added P gp inhibitor to ensure that the drug in the cell and up to 2