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目的探讨急性化脓性中耳炎病原菌及其耐药情况,以及病原菌的动态变化情况。方法本次研究选取2009~2011年(对照组)、2012~2014年(观察组)急性化脓性中耳炎各60例;分别进行细菌培养和药敏试验。结果从两组数据的结果显示可以看出,近5年总体的病原菌分布中前两位分别为金黄色葡萄球菌和肺炎链球菌,其地位没有变化,而黑曲菌和流感嗜血杆菌的上升幅度较大。观察组的60例急性化脓性中耳炎的致病菌耐药情况中显示,金黄色葡萄球菌耐药率较高的抗生素为红霉素(75.4%),肺炎链球菌耐药率较高的抗生素为红霉素(88.6%),流感嗜血杆菌耐药率最高的抗生素为青霉素(51.1%)。结论近5年总体的病原菌分布中前两位分别为金黄色葡萄球菌和肺炎链球菌,黑曲菌和流感嗜血杆菌的生生幅度较大。急性化脓性中耳炎致病菌对青霉素和红霉素的耐药率较高,可根据患者对药物敏感度测试的结果来选择药敏性较高的药物进行治疗,提高治疗效果。“,”Objective To investigate the acute suppurative otitis media pathogenic bacteria and their drug resistance, as wel as the dynamic changes of the pathogen. Methods This study selected 2009~2011 (control group), 2012-2014 (observation group) with acute suppurative otitis media each 60 cases;For bacterial culture and drug sensitive test, respectively. Results Can be seen from the two groups of data results show that, in recent five years the overal distribution of pathogenic bacteria first two were staphylococcus aureus and streptococcus pneumoniae, its status has not changed, and the black music bacterium and h. influenzae rise is larger. Observation group of 60 cases of acute suppurative otitis media of pathogenic bacteria resistant cases showed that staphylococcus aureus, higher percentages of antibiotics for erythromycin (75.4%), s. pneumoniae, higher percentages of antibiotics for erythromycin (88.6%), haemophilus influenzae brains to the highest rate of antibiotics for penicil in (51.1%). Conclusion In recent five years of pathogenic bacteria distribution of the top two were staphylococcus aureus and streptococcus pneumoniae, black music bacterium and h. influenzae living too. Acute suppurative otitis media pathogenic bacteria to penicil in and erythromycin resistant rate is higher, can according to the results of drug sensitivity test in patients with selecting drug sensitivity was higher for treatment, improve the ef ect of treatment.