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方法：分别给易卒中型肾血管性高血压大鼠、正常血压大鼠饲以高脂饲料６周和１６周，在电镜下观察其脑动脉内皮糖萼的变化。结果：高胆固醇可引起大鼠颈内动脉、大脑中动脉内皮糖萼变薄、分布不均匀，常伴缺失、结块现象，且高胆固醇时间越久、损害越严重。高血压也可引起大鼠大脑中动脉内皮糖萼同样的改变。这在增加脑血管的通透性，促进脂质的沉积和动脉粥样硬化的形成中可能起重要作用。
Methods: Stroke-prone renovascular hypertensive rats and normotensive rats were fed with high-fat diet for 6 weeks and 16 weeks respectively. The changes of endothelium glycocalyx were observed under electron microscope. Results: Cholesterol can cause internal carotid artery and middle cerebral artery in rats. The inner glycocalyx is thin, uneven distribution, often accompanied by missing, caking phenomenon, and the longer the high cholesterol, the more serious the damage. Hypertension can also cause the same changes in the rat middle cerebral artery calyx. This may play an important role in increasing cerebral vascular permeability, promoting lipid deposition and atherosclerosis formation.