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28只输精管结扎家免,以20只同龄雄免作对照。分10、13、16、22月组进行观察。光镜观察表明,10月组曲细精管呈弥漫性萎缩,生精过程停止。16、22月组除少数曲细精管极度萎缩被结缔组织包绕外,大多数曲细精管恢复正常生精过程。电镜发现,术后16、22月组生精过程活跃,Sertoli细胞与Leydig细胞无明显异常。血浆睾酮水平10月组明显低于正常,13月后恢复正常。曲细精管平均细胞数、平均截面积与血浆睾酮水平正相关(P<0.01),与血清抗精子抗体滴度无相关性(P>0.05)。极度萎缩的曲细精管及其周围可见免疫复合物沉积,余者为阴性。
28 vasectomies home-free, with 20 same-age male as a control. Points 10, 13, 16, 22 months to observe the group. Light microscopy showed that the seminiferous tubules in October were diffuse atrophy, spermatogenesis stopped. In 16 and 22 months, most seminiferous tubules returned to normal spermatogenesis except for a few seminiferous tubules that were extremely contracted by connective tissue. Electron microscopy showed that the process of spermatogenesis was active in 16 and 22 months after operation, and there was no obvious abnormalities in Sertoli cells and Leydig cells. The level of plasma testosterone in October group was significantly lower than normal, returned to normal after 13 months. Mean cell number and average cross-sectional area of seminiferous tubules were positively correlated with plasma testosterone levels (P <0.01), but not with serum anti-sperm antibody titers (P> 0.05). The seminiferous tubules and their surroundings showed the deposition of immunocomplex, with the remaining negative.