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目的 提高对艾滋病 (AIDS)合并隐球菌脑膜炎的认识。方法 对赤道几内亚巴塔地区医院 18例AIDS合并隐球菌脑膜炎患者进行临床综合分析。结果 18例AIDS合并隐球菌脑膜炎患者的临床主要表现为 :发热、剧烈头痛、极度乏力、肢体痛、脑膜刺激征及消瘦与脱水等。脑脊液 (CSF)培养均为新型隐球菌生长 ;涂片及隐球菌多糖荚膜抗原 (ELISA法 )检测的阳性率分别为 77 8% (14/ 18) ,94 4% (17/ 18)。结论 隐球菌脑膜炎为AIDS常见机会性感染及主要致死病因之一。
Objective To improve AIDS awareness of cryptococcal meningitis. Methods 18 patients with cryptococcal meningitis complicated with AIDS in Batata district hospital of Equatorial Guinea were analyzed comprehensively. Results The clinical manifestations of 18 cases of AIDS with cryptococcal meningitis were as follows: fever, severe headache, extreme fatigue, limb pain, meningeal irritation and weight loss and dehydration. Cerebrospinal fluid (CSF) culture was the growth of Cryptococcus neoformans. The positive rates of smear and cryptococcal polysaccharide capsular antigen (ELISA) were 77 8% (14/18) and 94 4% (17/18), respectively. Conclusion Cryptococcal meningitis is a common opportunistic infection of AIDS and one of the major causes of death.