论文部分内容阅读
地方性氟中毒是以氟斑牙、氟骨症为主要表现的全身性疾病,主要由于过量的氟在体内蓄积,造成牙齿、骨骼、横纹肌等组织器官的慢性中毒。近年来随着防治研究工作的深入开展,对治疗氟中毒的药物进行了多项研究,但目前仍缺乏疗效显著、又便于推广的抗氟药物。本实验用高氟水致大鼠氟中毒,同时分组给予硼、硒、氟宁、苁蓉等抗氟药物。通过测定血清磷、硷性磷酸酶、尿氟等有关生化指标,研究氟中毒时大鼠体内生化代谢的改变以及几种药物的抗氟效果,以便为临床防治筛选较佳
Local fluorosis is a systemic disease mainly characterized by dental fluorosis and skeletal fluorosis. It is mainly caused by excessive accumulation of fluoride in the body, resulting in chronic poisoning of tissues and organs such as teeth, bones and striated muscles. In recent years, with the further development of prevention and treatment work, many studies have been conducted on drugs for treating fluorosis. However, there are still a lot of anti-fluoro drugs that have obvious curative effect and are easy to be popularized. In this experiment, fluoride poisoning caused by high fluoride water was given to rats, while antifluorine drugs such as boron, selenium, fluridine and cistanche were given in groups. Through the determination of serum phosphorus, alkaline phosphatase, urinary fluoride and other biochemical indicators to study fluorosis in rats when the biochemical metabolism changes and the anti-fluoride effect of several drugs in order to screen for better clinical prevention