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目的:研究抗生素致肠道菌群失调性腹泻(antibiotic associated diarrhea,AAD)患儿治疗前后血清降钙素原(procalcitonin,PCT)水平变化及其在临床上的应用价值。方法:选择2011年6月~2013年6月于我院住院治疗的AAD患儿158例作为观察组,选取同期来院体检的健康儿童66例作为对照组,免疫组化发光法检测并比较患儿血清PCT水平。分析AAD患儿血清PCT水平与患儿年龄及性别的关系。结果:观察组治疗前血清PCT水平明显高于对照组(P<0.01)。观察组治疗后血清PCT水平明显低于治疗前水平(P<0.01)。Spearman相关性分析显示,AAD患儿血清PCT水平与性别、年龄均无相关关系(P>0.05)。结论:血清PCT水平在临床上可作为AAD的早期检测指标对该病的诊断及治疗预后判断起到一定的指导作用。
Objective: To investigate the changes of serum procalcitonin (PCT) levels in patients with antibiotic associated diarrhea (AAD) before and after treatment and their clinical value. Methods: A total of 158 AAD children hospitalized in our hospital from June 2011 to June 2013 were selected as the observation group. Sixty-six healthy children were selected as control group during the same period of hospitalization. Immunohistochemical luminescence was used to detect and compare children Serum PCT levels. Analysis of AAD children with serum PCT levels and age and gender in children. Results: The serum PCT level in observation group before treatment was significantly higher than that in control group (P <0.01). The level of serum PCT in the observation group after treatment was significantly lower than that before treatment (P <0.01). Spearman correlation analysis showed that there was no correlation between serum PCT level and gender and age in children with AAD (P> 0.05). Conclusion: The level of PCT in serum can be used as an early detection index of AAD to guide the diagnosis and prognosis of AAD.