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目的对联合雾化方法治疗慢阻肺急性加重期的效果进行探讨。方法将130例患者随机分为观察组和对照组,其中观察组采用布地奈德联合沙丁胺醇组治疗,而对照组单用沙丁胺醇治疗,观察两组治疗前后的肺功能、临床疗效和不良反应。结果治疗结束后,观察组的各项肺功能指标与对照组比较差异具有统计学意义(P﹤0.05),观察组的肺功能指标显著优于对照组。治疗结束后观察临床疗效,观察组的临床疗效与对照组比较差异有统计学意义(P﹤0.05),观察组的临床疗效明显优于对照组。2例观察组患者发生轻度咽部不适症状,1例患者的血糖水平升高;对照组2例出现心悸,1例患者出现手抖,但以上不良反应均为轻度,经对症处理后症状均消失。经统计学比较,两组患者不良反应的发生率无明显差异性(P﹥0.05)。结论布地奈德联合沙丁胺醇雾化吸入治疗AECOPD具有一定的实用价值。
Objective To explore the effect of combined atomization on acute exacerbation of chronic obstructive pulmonary disease. Methods 130 patients were randomly divided into observation group and control group. The observation group was treated with budesonide combined with salbutamol, while the control group was treated with salbutamol alone. The pulmonary function, clinical efficacy and adverse reactions were observed before and after treatment. Results After the treatment, the pulmonary function indexes in the observation group were significantly different from those in the control group (P <0.05). The pulmonary function indexes in the observation group were significantly better than those in the control group. Clinical efficacy was observed after the treatment, the clinical efficacy of the observation group compared with the control group, the difference was statistically significant (P <0.05), the clinical efficacy of the observation group was significantly better than the control group. Two patients in the observation group had mild pharyngeal discomfort and one patient had elevated blood glucose levels. Two patients in the control group had palpitations and one patient had tremor. However, the above adverse reactions were mild and symptomatic after treatment All disappear. By statistical comparison, there was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions Budesonide combined with salbutamol inhalation for the treatment of AECOPD has some practical value.