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目的了解杭州地区性病门诊患者人乳头状瘤病毒(HPV)临床流行病学情况,为HPV感染的防治提供依据。方法选择300例性病门诊患者,其中150例尖锐湿疣(CA)患者和150例无CA的患者。CA患者取疣体组织,无CA患者男性取龟头和冠状沟表面细胞组织,女性取宫颈管细胞组织,提取DNA后进行HPV基因芯片杂交分型。结果 300例患者中单一型HPV感染150例,双重、三重、四重和五重HPV感染分别为24例、10例、6例和3例。CA患者和无CA患者均以低危型HPV6和11最常见,高危型则以HPV16、33、52、58和68较为常见。150例无CA的患者中也有55例HPV检测阳性,阳性率高达36.7%。女性HPV多重感染性率16.42%高于男性的3.6%(P<0.01)。结论杭州地区性病门诊患者以低危型HPV6和11感染为主,无CA的性病门诊患者也具有较高的HPV感染率。
Objective To understand the clinical epidemiology of human papilloma virus (HPV) in STD clinics in Hangzhou and provide evidence for the prevention and treatment of HPV infection. Methods 300 STD clinic patients were selected, including 150 cases of condyloma acuminatum (CA) and 150 cases of non-CA patients. CA patients wart body tissue, no CA patients male glans and coronal groove surface cells, cervical uterine cervix tissue cells, DNA extraction after HPV gene chip hybridization. Results A total of 150 cases of single type HPV infection were found in 300 patients. The double, triple, quadruple and quadruple HPV infections were 24, 10, 6 and 3, respectively. The most common low-risk HPV types 6 and 11 and the high-risk type HPV types 16, 33, 52, 58 and 68 are common in patients with and without CA. In 150 cases of CA-free patients, 55 cases of HPV test positive, the positive rate was as high as 36.7%. The multiple HPV infection rate of females was 16.42% higher than that of males (3.6%) (P <0.01). Conclusion STD clinics in Hangzhou are mainly infected with low-risk HPV6 and HPV11, and STD clinics without CA also have higher rates of HPV infection.