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目的探讨COOK促宫颈成熟球囊用于中期妊娠依沙吖啶引产术中的临床效果及安全性。方法收集2011年1月-2012年12月孕16~28周引产者74例,随机分为研究组和对照组。研究组35例采用依沙吖啶羊膜腔注射联合COOK促宫颈成熟球囊引产,对照组39例采用依沙吖啶羊膜腔注射引产,比较两组引产临床效果和安全性。结果研究组羊膜腔注射后至规律子宫收缩(宫缩)时间、规律宫缩至胎盘娩出时间和胎盘胎膜残留率分别为(29.68±4.17)h、(7.63±2.30)h和28.6%(10/35),对照组分别为(33.60±5.38)h、(9.86±3.20)h和56.4%(22/39),两组比较差异均有统计学意义(P<0.05);研究组引产出血量和引产成功率分别为(81.60±17.64)m L和100.0%(35/35),对照组分别为(83.82±15.08)m L和94.9%(37/39),差异无统计学意义(P>0.05)。结论 COOK促宫颈成熟球囊在中期妊娠依沙吖啶引产术中可缩短引产时间、减少胎盘胎膜残留,减轻产妇痛苦,值得应用推广。
Objective To investigate the clinical effect and safety of COOK-induced cervical mature balloon in induction of ethacridine in mid-term pregnancy. Methods 74 cases of induced abortion were collected from January 2011 to December 2012 in the period of 16-28 weeks and were randomly divided into study group and control group. In the study group, 35 cases were treated with cisplatin inhalation combined with COOK to induce labor of mature cervical balloon. In the control group, 39 cases were injected with amniotic fluid through the amniotic cavity. The clinical effects and safety of induced abortion were compared between the two groups. Results The time from regular contractions of the uterus to the regular uterine contractions (uterine contractions), regular contractions to the placenta and fetal membranes were (29.68 ± 4.17) h, (7.63 ± 2.30) h and 28.6% (10 / 35), and the control group were (33.60 ± 5.38) h, (9.86 ± 3.20) h and 56.4% (22/39), respectively. There were significant differences between the two groups (P <0.05) (81.60 ± 17.64) m L and 100.0% (35/35) respectively in the control group and (83.82 ± 15.08) m L and 94.9% (37/39) in the control group, respectively, with no significant difference (P> 0.05). Conclusion COOK promoting cervical mature balloon induction of labor in the second trimester of ethacridine can shorten the time of induction of labor, reduce the residual placental membranes, reduce the pain of maternal, it is worth to promote the application.