近几年用炔羟雄烯唑(danazol一种减弱的雄激素)治疗遗传性血管性水肿取得成功,其作用机理目前尚未弄清。据发现,600mg/d 的剂量可以提高 C_1INH(激活 C_1的抑制剂)水平,使之恢复正常或接近正常,从而阻止诱发血管性水肿发作的补作(C_2和 C_4)的激活。然而小剂量的炔羟雄烯唑几乎不能影响 C_1INH 水平和阻止血管性水肿发作,因此,炔羟雄烯唑有可能增加某些补偿 C_1INH In recent years with alkyne androsterone (danazol a weakened androgen) treatment of hereditary angioedema success, its mechanism of action has not yet been clarified. It was found that a dose of 600 mg / d increased levels of CINH, an inhibitor of C-1 activation, back to normal or nearly normal, thereby preventing activation of supplements (C_2 and C_4) that induce episodes of angioedema. However, small doses of alkyne androstenedrazole barely affect the level of C 1INH and prevent the onset of angioedema; therefore, alkyne androsterone may increase some compensatory C_1INH