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目的探讨中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在肺癌性胸腔积液的变化情况,分析其对恶性胸腔积液的诊断价值。方法 64例肺癌伴胸腔积液患者作为肺癌组,60例良性胸腔积液患者作为良性组。比较两组胸腔积液中NGAL水平及肺癌组不同病理特征肺癌患者胸腔积液NGAL水平的差异。结果肺癌组患者胸腔积液NGAL水平(61.84±10.59)ng/ml高于良性组患者的(48.32±8.11)ng/ml,差异有统计学意义(P<0.05)。胸腔积液NGAL水平与肺癌病理类型无关(P>0.05);肿瘤直径越大,淋巴结转移越多,分化程度越低的患者,其胸腔积液中NGAL水平越高,差异有统计学意义(P<0.05)。结论肺癌性胸腔积液中NGAL水平显著高于良性胸腔积液,并且其水平与肿瘤大小、分化程度及淋巴结转移情况相关,可作为恶性胸腔积液的判断指标,并用于评价肺癌恶性程度。
Objective To investigate the changes of neutrophil gelatinase-associated lipocalin (NGAL) in lung cancer with pleural effusion and to evaluate its diagnostic value for malignant pleural effusions. Methods Sixty-four patients with lung cancer with pleural effusion were selected as the lung cancer group and 60 patients with benign pleural effusion as the benign group. NGAL levels in pleural effusion were compared between two groups and lung cancer patients with different pathological features of lung cancer patients pleural effusion NGAL levels were different. Results The level of NGAL in pleural effusion in lung cancer patients was significantly higher than that in benign patients (61.84 ± 10.59) ng / ml (48.32 ± 8.11) ng / ml, the difference was statistically significant (P <0.05). The level of NGAL in pleural effusion was not related to the pathological type of lung cancer (P> 0.05). The larger the diameter of the tumor, the more lymph node metastasis, the lower the differentiation degree, the higher the level of NGAL in pleural effusion was, the difference was statistically significant (P <0.05). Conclusions The level of NGAL in lung cancer with pleural effusion is significantly higher than that in benign pleural effusions. The level of NGAL is correlated with tumor size, differentiation and lymph node metastasis, which can be used as a diagnostic indicator of malignant pleural effusion and to evaluate the malignancy of lung cancer.