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目的探讨硒蛋白-P其在大肠癌发生、发展中的作用。方法采用免疫组化方法检测81例大肠癌组织、转移淋巴结和20例癌旁正常黏膜组织中硒蛋白-P的表达,分析其与患者临床病理参数的关系。结果硒蛋白-P在大肠癌组织及转移淋巴结组织中的阳性表达率分别为53.1%和55.7%,在正常黏膜组组织中的阳性表达率为80%(16/20),后者明显高于前两者(P<0.05),硒蛋白-P在大肠癌组织中的表达与患者其他病理学因素无关。结论硒蛋白-P在大肠癌组织中表达降低,提示其在大肠癌的发生、发展中可能起重要作用。但不能作为判断预后的指标。
Objective To investigate the role of selenoprotein-P in the occurrence and development of colorectal cancer. Methods Immunohistochemical method was used to detect the expression of selenoprotein-P in 81 cases of colorectal cancer tissues, metastatic lymph nodes and 20 cases of normal mucosa tissues. The relationship between selenoprotein-P and clinicopathological parameters was analyzed. Results The positive expression rates of selenoprotein-P in colorectal carcinoma tissues and metastatic lymph nodes tissues were 53.1% and 55.7%, respectively. The positive expression rate of selenoprotein-P in normal mucosa tissues was 80% (16/20), which was significantly higher than The former two (P <0.05), selenoprotein-P expression in colorectal cancer tissue has nothing to do with other pathological factors. Conclusion The expression of selenoprotein-P in colorectal cancer is decreased, suggesting that selenoprotein-P may play an important role in the occurrence and development of colorectal cancer. But not as a prognostic indicator.