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AIM: Review of evidence that the 33-amino-acidpolypeptide secretoneurin, which is generated byproteolytic cleavage of secretogranin Ⅱ, plays a role inneurogenic inflammation. METHODS: Survey of theliterature using a MEDLINE search database. RE-SULTS: Secretoneurin is synthesized in spinalganglia, transported through the dorsal roots and storedin the axon terminals of primary afferent neurons.Investigations using capsaicin suggest that secretoneurinfunctions as an excitatory transmitter. Secretoneurinspecifically activates various cell functions including thechemotactic migration of monocytes, eosinophils,fibroblasts, smooth muscle cells, and endothelial cells,
AIM: Review of evidence that the 33-amino-acid polypeptide secretoneurin, which is generated by proteolytic cleavage of secretogranin II, plays a role in inurogenic inflammation. METHODS: Survey of the literatures using a MEDLINE search database. RE-SULTS: Secretoneurin is synthesized in spinal ganglia, transporting through the dorsal roots and storedin the axon terminals of primary afferent neurons. Investigations using capsaicin suggest that secretoneurinfunctions as an excitatory transmitter. Secretoneurinspecifically activates various cell functions including the chemotactic migration of monocytes, eosinophils, fibroblasts, smooth muscle cells, and endothelial cells,