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本文报告了105例慢性粒细胞白血病(简称慢粒)的染色体检查结果。其中103例(98.1%)为Ph~1染色体阳性,包括1例复杂的Ph~1易位和1例遮蔽的Ph~1易位。2例(1.9%)为Ph~1染色体阴性。骨髓Ph~1(+)细胞总出现率为95.4%。14例慢粒急变患者中10例伴有额外的染色体异常(71.4%),最多见的改变为2Ph~1、i(17q)和+8。并结合文献就Ph~1阴性慢粒的重新评价,骨髓Ph~1(+)细胞出现率和治疗的关系,慢粒急变的染色体变化及其预后意义等作了简要讨论。
This article reports 105 cases of chronic myeloid leukemia (referred to as CML) chromosome test results. Among them, 103 (98.1%) were Ph ~ 1 positive, including 1 complicated Ph ~ 1 translocation and 1 occluded Ph ~ 1 translocation. Two cases (1.9%) were Ph ~ 1 chromosome negative. The total occurrence rate of bone marrow Ph ~ 1 (+) cells was 95.4%. Ten of the 14 patients with chronic myo- cardia were associated with an additional chromosomal abnormality (71.4%), the most common of which were 2Ph-1, i (17q) and +8. In the light of the review of the literature, the reevaluation of Ph ~ 1 negative chronic granulocyte, the relationship between the occurrence and treatment of Ph ~ 1 (+) cells in bone marrow and the chromosome aberration and its prognostic significance.