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作者应用阿糖肌苷(Ara-A)治疗慢性肝炎11例,发现有3例出现Ara-A神经病,兹介绍如下(Ara-A神经病过去无报道)。 3例患者均为男性,年龄24～34岁。1例29天内静滴该药16.8g,后又连续口服64天共34.8g,总量为51.6g,在改为口服1个月余后出现两腓肠肌疼痛和僵硬,口服近2个月时两足底有痛性感觉异常与感觉减退,并于2周内上升到两膝,以后又有指尖发麻。另2例均于4周内静滴16.8g,休息20天后,再口服该药70天共37.8g,总量为54.6g,2例均在口服2个
The authors applied Ara-A to treat 11 cases of chronic hepatitis and found Ara-A neuropathy in 3 cases, as follows (Ara-A neuropathy was previously reported). Three patients were male, aged 24 to 34 years. 1 case of intravenous infusion of the drug within 16 days of 16.8g, and then continuous oral 64 days a total of 34.8g, a total of 51.6g, to more than 1 month after oral administration of two gastrocnemius pain and stiffness, oral nearly 2 months when two Plantar painful feeling abnormalities and feelings of diminished, and rose to knees within 2 weeks, then there are finger numbness. The other two cases were intravenous infusion of 16.8g within 4 weeks, 20 days after resting, and then oral administration of the drug for a total of 37.8g for 70 days, a total of 54.6g, 2 patients were orally 2