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【目的】了解妇幼保健医院多重耐药菌（MDRB）的检出情况和耐药趋势，为预防和治疗临床感染提供实验室依据。【方法】对湖南省妇幼保健院2008年1月至2012年12月临床分离的MDRB鉴定和药敏试验结果进行回顾性分析。【结果】五年分离MDRB 1648株，检出率呈环比逐年升高的趋势（ P ＜0．05），其中革兰阴性菌59．64％高于革兰阳性菌40．36％的检出率（ P ＜0．05）。MDRB革兰阴性菌中，肠杆菌科菌对美洛培南高度敏感，铜绿假单胞菌和鲍氏不动杆菌广泛多重耐药；M D RB革兰阳性菌中耐甲氧西林葡萄球菌（MRS）未发现耐万古霉素菌株。【结论】近五年来该院送检标本MDKB检出率呈上升趋势，革兰阴性菌所占比重较高，且耐药情况严重。妇幼保健医院婴童患者免疫功能不大成熟及孕产妇免疫功能低下，定期进行细菌耐药的监测对预防和治疗临床感染更显重要。“,”[Objective]To understand the detection status of multidrug-resistant bacteria(MDRB) and the trend of drug resistance in order to provide experimental data for prevention and therapy of clinical infection .[Methods]The results of MDRB identification and drug sensitive test in maternal and child health hospital of Hunan province from Jan .2008 to Dec .2012 were analyzed retrospectively .[Results]Totally 1648 strains of MDRB were isolated in 5 years and the detection rate showed the rising trend year by year ( P<0 .05) .Among them ,Gram-negative bacteria accounted for 59 .64% ,which was higher than that of Gram-positive bacteria (40 .36% )( P <0 .05) .In Gram-negative bacteria of MDRB ,Enterobacteriaceae bacteria were highly sensitive to meropenem ,while pseudomonas aeruginosa and Baumannii acinetobacter were widespread multidrug-resist-ance .Vancomycin resistant strains were not found in methicillin-resistant staphylococcus aureus (MRS) of Gram-positive bacteria of MDRB .[Conclusion]The detection of MDRB in collection samples of the hospital in recent 5 years .Gram-negative bacteria account for the higher proportion and reveal serious drug resistance . Since infant and child patients have immature immune function and pregnant women have weakened immune function in maternal and child health hospital ,regular monitoring of bacterial resistance are more important for the prevention and treatment of clinical infection .