恶性肿瘤中耐受辐射的缺氧细胞的存在使放疗只取得有限的效果。为解决这一问题,或采用高压氧仓,或用快中子等粒子束照射,但因设备昂贵,不易推广使用,而辐射致敏剂使用方便,有希望成为放疗的辅佐药物之一。近年来有关辐射致敏剂的研究取得较大的进展。早在1954年,Langendorff报道照射前给小鼠碘乙酸增加了小鼠死亡率。1960年,Bridges报道N-乙基马来酰亚胺对大肠捍菌有辐射致敏作用。其后,Adams及其同事和Chapman等的工作促 The presence of radiation-tolerant cells in malignancies leads to limited success with radiotherapy. To solve this problem, or the use of hyperbaric oxygen chamber, or the use of fast neutron particle beam irradiation, but because of expensive equipment, not easy to promote the use of radiation sensitizers easy to use, promising to become one of adjuvant radiotherapy. In recent years, research on radiation sensitizers made great progress. As early as 1954, Langendorff reported that mouse iodine acetate increased mouse mortality before irradiation. In 1960, Bridges reported that N-ethylmaleimide has a radiosensitizing effect on colon bacilli. Since then, work by Adams and colleagues and Chapman et al