论文部分内容阅读
碱性成纤维细胞生长因子（ｂＦＧＦ）是一个促有丝分裂的蛋白质分子，是ＦＧＦ家族中最具代表性的成员。它具有高亲合力和低亲合力两类受体，以极微的含量正常存在哺乳动物和人体的中枢神经组织和外周其他组织中，对中胚层和神经外胚层来源的组织细胞有很强的促生长作用。当炎症或外伤时，浸润的巨噬细胞和受损伤的细胞可以释放以ｂＦＧＦ为主的细胞生长因子以促进创伤的修复。而ｂＦＧＦ广谱的神经营养活性将为多种神经系统疾病的治疗提供理论依据。
Basic fibroblast growth factor (bFGF) is a mitogenic protein molecule that is the most representative member of the FGF family. It has high avidity and low avidity two types of receptors, with a very small amount of normal existence of mammalian and human central nervous system and other tissues in the periphery, the mesoderm and neuroectodermal derived tissue cells have a strong Promote growth. Inflammatory macrophages and injured cells can release bFGF-based cell growth factors to promote wound healing when inflamed or traumatized. The bFGF broad-spectrum neurotrophic activity will provide a theoretical basis for the treatment of a variety of neurological diseases.