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研究了人正常膀胱和浅表性膀胱癌的粘膜/粘膜下层组织在300～900nm光谱范围的漫反射光谱特性及其差异,实验采用带积分球附件的分光光度计获取组织的漫反射光谱。结果表明,在300～900nm,正常膀胱的粘膜/粘膜下层对任一个波长的漫反射率都明显地较癌变的粘膜/粘膜下层对相应波长的要大。正常膀胱的粘膜/粘膜下层的漫反射光谱的峰分别在370nm、520nm、550nm和660nm,其峰值分别为52.4%、60.7%、56.1%和75.5%。而癌变的粘膜/粘膜下层的漫反射光谱的峰分别在320nm、520nm、550nm和660nm,其峰值分别为43.7%、33.4%、30.6%和70.2%。正常膀胱的粘膜/粘膜下层的漫反射光谱在370nm处有一个峰,而癌变的粘膜/粘膜下层的漫反射光谱在370nm处没有峰,320nm处有一个峰。而正常膀胱的粘膜/粘膜下层的漫反射光谱在320nm处没有峰。膀胱的粘膜/粘膜下层病变导致组织的漫反射光谱在520nm、550nm和660nm处的峰的峰值分别减小了45.0%、45.5%和7.02%。说明膀胱的粘膜/粘膜下层病变导致组织的组分和结构尤其是组织中的氧合血红蛋白和去氧血红蛋白的含量发生了明显的改变。
The diffuse reflectance spectra and differences of the mucosa / submucosa of human normal bladder and superficial bladder cancer in the spectral range from 300 to 900 nm were studied. The diffuse reflectance spectra of the tissues were obtained using a spectrophotometer with an integrating sphere attachment. The results show that at 300 ~ 900nm, the normal mucosa / submucosa of the bladder at any wavelength of diffuse reflectance are significantly more than the cancerous mucosa / submucosa to the corresponding wavelength larger. The peaks of the diffuse reflectance spectra of normal bladder mucosa / submucosa were at 370 nm, 520 nm, 550 nm and 660 nm, respectively, with peaks of 52.4%, 60.7%, 56.1% and 75.5%, respectively. The peaks of the diffuse reflectance spectra of cancerous mucosa / submucosa were at 320 nm, 520 nm, 550 nm and 660 nm, respectively, with peak values of 43.7%, 33.4%, 30.6% and 70.2% respectively. The diffuse reflectance spectrum of normal bladder mucosa / submucosa has a peak at 370 nm whereas the cancerous mucosa / submucosa has no peak at 370 nm and a peak at 320 nm. Whereas the diffuse reflectance spectrum of mucosa / submucosa of normal bladder has no peak at 320 nm. Mucosal / submucosal lesions of the bladder lead to a 46.0%, 45.5% and 7.02% reduction in peak peak intensity of the tissue at 520 nm, 550 nm and 660 nm, respectively. This shows that the mucosal / submucosal lesions of the bladder lead to significant changes in the content of oxyhemoglobin and deoxyhemoglobin in the components and tissues of the tissues, especially in the tissues.