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从伞形科植物大叶柴胡Bupleurum logiradiatum Turcz.的根及根茎中分得四种新的多烯炔类化合物,分别命名为柴胡毒素(bupleurotoxin,Ⅰ)柴胡酮醇(bupleuonol,Ⅱ),乙酰柴胡毒素(acetyl-bupleufotoxin,Ⅲ)和柴胡炔醇(bupleurynol,Ⅳ)。根据理化性质和光谱数据确定柴胡炔醇(Ⅳ)为十七碳三烯-(2z,8 E,10 E)-二炔-(4,6)-醇-1;柴胡毒素(Ⅰ)为14-羟基柴胡炔醇;乙酰柴胡毒素(Ⅲ)为14-乙酰氧基柴胡炔醇;柴胡酮醇(Ⅱ)为14-羰基柴胡炔醇。柴胡毒素(Ⅰ)和乙酰柴胡毒素(Ⅲ)有毒性。
From the roots and rhizomes of Umbelliferae Bupleurum logiradiatum Turcz., four new polyene acetylenic compounds were isolated and named as Bupleurotoxin (I) Bupleuonol (II). Acetyl-bupleufotoxin (III) and bupleurynol (IV). Based on physicochemical properties and spectral data, it was determined that chaiflunol (IV) is heptadecatriene-(2z,8E,10E)-diyne-(4,6)-ol-1; Bupleurum toxin (I) 14-Hydroxy cyanethenol; Acetylchutoxin (III) is 14-acetoxychaikonol; Cauzohydrin (II) is 14-carbonyl cainitinol. Bupleurum toxin (I) and acetylchocotoxin (III) are toxic.