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血浆高密度脂蛋白(HDL)水平与动脉粥样硬化的发生呈负相关。HDL中的一个主要成分是脱辅基脂蛋白A-I(apoli-poprotein A-I,简称apoA-I),它是HDL的主肽,受apoA-I基因控制。1983年Karathanasis等首先报告apoA-l基因位点多态性与过早发生动脉粥样硬化有关,第一次直接从基因水平探讨动脉粥样硬化发生的本质。由于他们的卓越贡献,获得了美国心脏协会当年颁发的佩奇青年研究人员奖。同年,Rees等又发现邻近apoA-I基因
The level of plasma high density lipoprotein (HDL) was negatively correlated with the occurrence of atherosclerosis. One of the major components of HDL is apoli-poprotein A-I (apoA-I), which is the main peptide of HDL and is controlled by the apoA-I gene. In 1983, Karathanasis et al first reported apoA-l gene polymorphism associated with premature atherosclerosis, the first time directly from the gene level to explore the nature of atherosclerosis. Because of their outstanding contribution, won the American Heart Association awarded the Peych Young Researcher Award. In the same year, Rees and so found that the adjacent apoA-I gene