心肌线粒体是心肌细胞的能量供应站、Ca~(2+)浓度调节器、细胞死亡执行者。病毒感染过程中病毒直接损害、免疫损害、氧自由基损伤使心肌线粒体的结构和功能发生改变,进而引起线粒体的钙超载、呼吸链功能障碍、凋亡、DNA损伤,最终使ATP合成受阻,心肌能量供应不足;膜离子运输系统紊乱,心肌异常电位产生;凋亡调控系统激活,心肌细胞发生凋亡。 Myocardial mitochondria are the energy supply stations of cardiomyocytes, Ca 2+ concentration regulators and cell death executors. During virus infection, the virus directly damages, the immune damage, the oxygen free radical damage causes the structure and function of myocardial mitochondria to change, and then causes the mitochondrial calcium overload, the respiratory chain dysfunction, the apoptosis, the DNA damage, finally hinders the ATP synthesis, Lack of energy supply; membrane ion transport system disorders, abnormal myocardial generation; activation of apoptosis regulatory system, myocardial cell apoptosis.