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顺铂为基础的联合化疗是鼻咽癌(nasopharyn-geal carcinoma,NPC)化疗常用的化疗方案,在综合治疗中占有重要的地位,然而肿瘤细胞对化疗耐药的产生,严重影响了化疗疗效,导致鼻咽癌生存率一直偏低。肿瘤细胞对化疗药物的耐受是多方面的,包括细胞内药物蓄积减少,药物灭活增强(如谷胱甘肽和金属硫蛋白),对DNA损伤的耐受性增加或损伤后的修复功能增强(DRC),肿瘤细胞对DDP作用DNA后形成的Pt-DNA的耐受性增加,其
Cisplatin-based combination chemotherapy is commonly used in the chemotherapy of nasopharynx-geal carcinoma (NPC), which plays an important role in the comprehensive treatment. However, the chemoresistance of tumor cells to chemotherapy has a serious impact on the efficacy of chemotherapy. Lead to nasopharyngeal carcinoma survival rate has been low. Tumor cells are resistant to chemotherapeutic drugs in many ways, including reduced intracellular drug accumulation, increased drug inactivation (eg, glutathione and metallothionein), increased tolerance to DNA damage, or repair function after injury Enhanced (DRC), the tolerance of tumor cells to Pt-DNA formed after DNA treatment of DDP is increased, which