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采用单克隆抗体酶联免疫吸附试验对5例年龄为2~8×8/12岁,反复呼吸道感染病儿的血清免疫球蛋白(Ig)G亚类作了测定,21名同龄健康小儿作为对照组.结果发现全部5例均有一种或一种以上IgG亚类缺乏:IgG_1缺乏症2例,IgG_2缺乏症、IgG_2—G_4缺乏症各1例,另1例常见变异型免疫缺陷病的血清4种IgG亚类均缺乏.该5例IgG亚类缺乏症的临床表现除反复上呼吸道感染外,尚有复发性口腔溃疡、反复脓皮病、急性中耳炎、慢性上颌窦炎、反复支气管炎.本文提示IgG亚类为一常见儿科疾病.
Serum immunoglobulin (Ig) G subgroups of 5 age-matched children with recurrent respiratory tract infections aged 2-8 × 8/12 years were measured by monoclonal antibody enzyme-linked immunosorbent assay (ELISA). Twenty-one healthy children of same age The results showed that all five patients had one or more IgG subclass deficiency: IgG1 deficiency in 2 cases, IgG2 deficiency, IgG2-G_4 deficiency in 1 case, and the other 1 case of common variant immunodeficiency disease serum 4 Of the IgG subclass are lacking in the clinical manifestations of the five cases of IgG subclass deficiency in addition to repeated upper respiratory tract infection, there are recurrent oral ulcers, pyoderma repeated, acute otitis media, chronic maxillary inflammation, recurrent bronchitis. Tip IgG subclass as a common pediatric disease.