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一、历史 1954年,Javier Arias-Stella在一次病理学年会上,宣读了他的一篇经典论文,题为《在滋养叶组织存在的情况下,子宫内膜非典型改变》。该文报导了182例流产,26例葡萄胎,14例绒毛膜上皮瘤,4例合体细胞子宫内膜炎及1例宫外孕。上述病例中有部分病例在组织病理学上均呈现相似的子宫内膜非典型改变。这些改变虽非少见,但并未被以前的病理学家所注意,文献及病理教科书上均未对此病变予以详述。此后,文献作者将具有与Arias-Stella所描述的相似的子宫内膜非典型改变称之为Arias-Stella反应或A-S征(Arias-Stella Sign)。
I. History In 1954, Javier Arias-Stella presented a classic treatise entitled “Atypical endometrial changes in the presence of nourishing leaf tissue” at a pathology conference. This article reports on 182 cases of abortion, 26 cases of hydatidiform mole, 14 cases of choriocarcinoma, 4 cases of syncytial endometritis and 1 case of ectopic pregnancy. Some of the above cases showed histopathological similar endometrial atypical changes. Although not uncommon, these changes have not been noticed by previous pathologists, and neither the literature nor the pathology textbook details the condition. Since then, the authors of the literature refer to the Arias-Stella reaction or the A-S sign (Arias-Stella Sign) as having atypical endometrial changes similar to those described by Arias-Stella.