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目的研究心肌炎患儿行磷酸肌酸与果糖二磷酸钠治疗的效果及对血清心肌肌钙蛋白Ⅰ的影响。方法 72例心肌炎患儿,按照治疗方法不同分成对照组和观察组,各36例。对照组患儿行磷酸肌酸治疗,观察组患儿行果糖二磷酸钠治疗。比较两组疗效和血清心肌肌钙蛋白Ⅰ、乳酸脱氢酶1、谷草转氨酶、外周血肌酸同工酶水平及不良反应发生情况。结果观察组治疗总有效率为97.22%,高于对照组的77.78%,差异具有统计学意义(χ~2=6.2222,P<0.05)。观察组血清心肌肌钙蛋白Ⅰ、乳酸脱氢酶1、谷草转氨酶、外周血肌酸同工酶水平均低于对照组,差异具有统计学意义(P<0.05)。两组总不良反应发生率比较差异无统计学意义(P>0.05)。结论心肌炎患儿行果糖二磷酸钠治疗能够提高疗效,优化患儿血清心肌肌钙蛋白Ⅰ水平,且不良反应少,可被临床推广及应用。
Objective To study the effect of creatine phosphate and sodium fructose diphosphate in children with myocarditis and its effect on serum cardiac troponin Ⅰ. Methods 72 cases of myocarditis in children, according to different treatment methods were divided into control group and observation group, each 36 cases. Children in the control group were treated with phosphocreatine, and children in the observation group were treated with fructose diphosphate. The curative effect of the two groups and serum cardiac troponin Ⅰ, lactate dehydrogenase 1, aspartate aminotransferase, peripheral blood creatine isoenzyme levels and adverse reactions were compared. Results The total effective rate of the observation group was 97.22%, which was higher than that of the control group (77.78%), the difference was statistically significant (χ ~ 2 = 6.2222, P <0.05). Serum levels of cardiac troponin Ⅰ, lactate dehydrogenase 1, aspartate aminotransferase, and peripheral blood creatine kinase were lower in the observation group than those in the control group, with statistical significance (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The treatment of myocarditis in children with fructose diphosphate treatment can improve the efficacy of optimizing serum cardiac troponin Ⅰ levels, and fewer adverse reactions, can be clinically promoted and applied.