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目的研究经亚低温治疗的重型脑损伤患者其外周血神经元特异性烯醇化酶(NSE)的动态变化及其临床意义。方法52例重型脑损伤患者随机分为亚低温组和对照组,前者进行亚低温治疗,后者除了不进行亚低温治疗外其他治疗方法与前者相同,分别于手术的次日、第2、3、5、7天测其外周血的NSE,满3个月进行GOS预后评分。结果发现经过一定时间的亚低温治疗,亚低温组外周血的NSE与对照组比较有明显的差异,满3个月进行GOS预后评分,亚低温组明显优于对照组(P＜0．05)。结论亚低温的确是治疗重型颅脑损伤的有效手段之一,其外周血NSE的动态变化能够准确反映治疗效果,而且简便易行,是评价重型脑损伤患者伤情及预后的客观指标之一。
Objective To investigate the dynamic changes of peripheral neuron-specific enolase (NSE) in patients with mild-type brain injury treated with mild hypothermia and its clinical significance. Methods Fifty-two patients with severe brain injury were randomly divided into mild hypothermia group and control group. The former was treated with mild hypothermia. The latter was the same as the former with no hypothermia treatment. On the next day of surgery, , 5,7 days measured peripheral blood NSE, GOS prognosis score of 3 months. The results showed that after a certain period of mild hypothermia, the NSE in the peripheral blood of the mild hypothermia group was significantly different from the control group. The GOS prognosis score was reached at 3 months, and was significantly better in the mild hypothermia group than in the control group (P <0.05) . Conclusion Mild hypothermia is indeed an effective treatment for severe craniocerebral injury. The dynamic changes of NSE in peripheral blood can accurately reflect the therapeutic effect and is simple and easy to be evaluated. It is one of the objective indexes to evaluate the severity of injury and prognosis in patients with severe brain injury.