洋地黄类药物的发现,距今巳有200多年的历史,现在临床上仍不失为治疗心衰和控制房颤的有效药物。目前最常用的洋地黄制剂仍为地高辛。随着洋地黄与抗心律失常药以及其他药物联合应用的不断增加,药物之间的相互作用屡见不鲜,可导致洋地黄疗效的增强或减弱、毒性的增加或降低。本文就此作一概述。 洋地黄与抗心律失常药的相互作用 1.洋地黄与奎尼丁 1978年Leahey等首先发现奎尼丁 The discovery of digitalis drugs, now has 200 years of history, is still clinically effective treatment of heart failure and atrial fibrillation. The most commonly used digitalis preparations are still digoxin. With the increasing use of digitalis and antiarrhythmic drugs and other drugs, the interaction between drugs is not uncommon, which can lead to the increase or decrease of the efficacy of digitalis, and the increase or decrease of toxicity. This article gives an overview of this. Digitalis and antiarrhythmic drug interactions 1. Digitalis and quinidine In 1978, Leahey first found that quinidine