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近年来对非小细胞肺癌的全身化疗探讨颇多,且有些报导证实,大剂量的顺铂与长春花碱酰胺联合应用疗效较好(有效率43%,中位生存期为22个月)。作者为重复该方案的疗效,并试图加用搏来霉素以提高疗效且不增加毒性,而设计了顺铂、长春花碱酰胺和搏来霉素(CVB)三联化疗方案。治疗未接受过化疗的肺鳞癌、腺癌和大细胞癌共54例。方法水化后,按Hayes 方法在第1和第29天各用顺铂120mg/m~2,同时用甘露醇利尿,此后每六周一次。长春花碱酰胺3 mg/m~2,每周一次快速静脉
In recent years, there have been many studies on systemic chemotherapy for non-small cell lung cancer, and some reports have confirmed that the combination of high doses of cisplatin and vinblastine has good efficacy (43% effective rate, median survival time is 22 months). The authors designed a triple chemotherapy regimen of cisplatin, vinblastine, and Bleomycin (CVB) by repeating the efficacy of this regimen and attempting to increase the efficacy without increasing the toxicity of bleomycin. A total of 54 lung squamous cell carcinomas, adenocarcinomas, and large cell carcinomas that had not received chemotherapy were treated. Methods After hydration, cisplatin 120 mg/m~2 was used on the 1st and 29th days according to the Hayes method, and urinary diuretic was used at the same time, every 6 weeks thereafter. Vinblastine amide 3 mg/m~2 once a week