目的探讨血浆内皮素 (ET)和肌酸激酶同工酶 MB(CK-MB)在脑心综合征患者发病机制中的作用和意义。方法观测 5 4例急性脑血管意外患者血浆 ET和 CK-MB水平的变化。结果与单纯脑血管意外组比较 ,脑心综合征急性期 ET显著性增高 ,而恢复期无差异 ;CK-MB则无显著变化。结论 ET异常增高在脑心综合征发病机制中的起着重要的作用 ,急性期应加以妥善处置 Objective To investigate the role and significance of plasma endothelin (ET) and creatine kinase MB (CK-MB) in the pathogenesis of patients with brain-heart syndrome. Methods The changes of plasma ET and CK-MB levels in 54 patients with acute cerebrovascular accident were observed. Results Compared with simple cerebrovascular accident group, the acute phase of brain-heart syndrome increased significantly ET, but no difference in convalescence; CK-MB had no significant change. Conclusion The abnormal increase of ET plays an important role in the pathogenesis of brain syndrome, and should be properly handled in acute stage