物种变化反应性与药物研究众所周知,药物研究的一个重要问题是缺乏动物到人数据转化的关系,这特别涉及到药动学的结果,因为药物在很大程度上被酶钝化或活化,此外药物的生物转化也造成揭示构效关系的困难。这种关系的药动学不失真的数量化和它的理化解释都要求从物理和立体化学上 Reproductive Reactivity and Drug Research It is well-known that one of the major problems in drug research is the lack of animal-to-human data conversion. This involves, in particular, the result of pharmacokinetics as the drug is largely passivated or activated by enzymes and, in addition, Biotransformation of the drug also causes difficulties in revealing the structure-activity relationship. The quantitative quantification of the pharmacokinetics of this relationship and its physicochemical interpretation require both physical and stereochemical