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为了评价硝酸甘油 (NTG)治疗充血性心力衰竭 (CHF)的疗效 ,将125例CHF患儿随机分为两组 ,NTG组 (A组 )75例 ,常规治疗组 (B组 )50例 ,观察两组的临床疗效。NTG组6例患儿在应用小剂量NTG(0.1～0.5) μg/(kg·min)治疗前后 ,应用超声心动图测定肺毛细血管楔压 (PCWP)、肺动脉平均压 (PAMP)、射血分数 (EF)、短轴缩短率 (FS)。结果 :NTG组临床疗效明显优于常规治疗组 ;小剂量NTG明显降低患儿PCWP(P<0.01) ,而对PAMP、EF、FS无明显影响。提示对CHF患儿在常规治疗 (地高辛 +卡托普利 +利尿剂 )的基础上 ,合用NTG疗效显著 ,而且优于常规治疗组
To evaluate the efficacy of nitroglycerin (NTG) in the treatment of congestive heart failure (CHF), 125 CHF children were randomly divided into two groups: 75 patients in NTG group (A group) and 50 patients in conventional therapy group (B group) Clinical efficacy of the two groups. Before and after treatment with NTG (0.1-0.5) μg / (kg · min) in 6 patients in NTG group, pulmonary capillary wedge pressure (PCWP), mean pulmonary artery pressure (PAMP), ejection fraction (EF), short axis shortening (FS). Results: The clinical efficacy of NTG group was significantly better than that of conventional treatment group. Low dose NTG significantly reduced PCWP in children (P <0.01), but had no significant effect on PAMP, EF and FS. It is suggested that the combination of NTG and conventional treatment (digoxin + captopril + diuretic) based on the treatment of CHF patients is significant and superior to the conventional treatment group