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[目的]探讨影响肺癌长期生存的因素。方法对1983年1月至1992年12月间收治的经病理证实的存活5年以上的72例肺癌患者进行分析。放疗采用60Co-r线或10MV-X线,大野前后对穿照射Dr40Gy/20次,共4周后缩野加量至总DT52G6y-76Gy(平均61.6Gy,非手术者)或50Gy-70Cy(平均56.1Gy,手术者)。手术均为肺叶(段)切除术。化疗主要方案为(CTX+5-FU+VCR、CTX+ADM+DDP、CTX+5-FU+CBP/E-ADM+VP-16等。[结果]临床分期、病理类型和是否加用手术治疗对5年生存率的影响,分析显示有统计学差异。I、II、III、IV期5年生存率分别为42.9%、12.9%、5.8%及0;小细胞未分化癌与非小细胞癌的5年生存率分别为3.2%和96%;手术加放疗(加或不加化疗)与放疗(加或不加化疗)的5年生存率分别为对.5%和5.5%。而放疗剂量及是否加化疗对5年生存率的影响未显示有统计学差异。[结论]肺癌应进行早期诊断、早期治疗,尽量采取以手术为主的综合治疗,以提高远期生存率。
[Objective] To explore the factors affecting the long-term survival of lung cancer. Methods The pathologically confirmed 72 patients with lung cancer who survived for more than five years and were admitted between January 1983 and December 1992 were analyzed. Radiotherapy using 60Co-r line or 10MV-X line, before and after the Ohno radiation exposure Dr40Gy / 20 times, a total of 4 weeks after the shrinkage field to the total DT52G6y-76Gy (average 61.6Gy, non-operator) or 50Gy-70Cy ( An average of 56.1 Gy, the operator). Surgery is lung (segment) resection. The main chemotherapy regimens were (CTX+5-FU+VCR, CTX+ADM+DDP, CTX+5-FU+CBP/E-ADM+VP-16, etc.) [Results] Clinical stage, pathological type, and whether or not surgery was used to treat the 5-year survival rate showed statistical differences. The 5-year survival rates for stage I, II, III, and IV were 42.9%, 12.9%, 5.8%, and 0, respectively; the five-year survival rates for small cell undifferentiated and non-small cell carcinomas were 3 The 2-year and 5-year survival rates for surgery plus radiotherapy (with or without chemotherapy) and radiotherapy (with or without chemotherapy) were 0.5% and 5.5%, respectively. The effect on 5-year survival rate did not show a statistical difference.[Conclusion] Lung cancer should be diagnosed early and treated early, and comprehensive treatment based on surgery should be adopted to improve long-term survival.