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目的 研究载脂蛋白E(ApoE)基因多态性与2型糖尿病伴冠心病(CAD)死亡危险性的关系。方法 对老年2型糖尿病伴CAD患者进行了3～8年的追踪研究,采用PCR/ASO探针杂交技术检测其ApoE基因型,其中Apo∈4携带者27例、∈3携带者45例、∈2携带者24例。结果 (1)与∈2携带者相比,∈4携带者血总胆固醇、低密度脂蛋白胆固醇及脂蛋白(a)水平明显增高(P<0.05)。(2)∈4携带者CAD死亡率为51.9%,明显高于∈2携带者(8.3%)(P<0.05)。结论 ∈4等位基因与老年2型糖尿病伴CAD患者死亡的危险性增高有关
Objective To investigate the association between apolipoprotein E (ApoE) gene polymorphism and the risk of type 2 diabetes with coronary heart disease (CAD). Methods Aged 3-to-8 years follow-up studies were performed in elderly patients with type 2 diabetes mellitus and CAD. ApoE genotypes were detected by PCR / ASO probe hybridization. Among them, 27 cases were carriers of Apoε4 and 45 cases were carriers of ε3 2 carriers in 24 cases. Results (1) The levels of blood total cholesterol, low density lipoprotein cholesterol and lipoprotein (a) in ∈4 carriers were significantly higher than those in ∈2 carriers (P <0.05). (2) The CAD death rate of ∈4 carriers was 51.9%, which was significantly higher than that of ∈2 carriers (8.3%) (P <0.05). Conclusion The ε4 allele is associated with an increased risk of death from type 2 diabetes in elderly patients with CAD