CYFRA_(21-1)是细胞角蛋白CK19的片段,单抗BM19-21和KS19-9能特异地识别该片段。各种上皮细胞均有不同的角蛋白,当上皮细胞转化为肿瘤细胞时,尽管角蛋白组成不变,但其含量会有不同程度增高。因此,可做为一项肿瘤标志物测定。本文报告应用免疫放射分析(IRMA)检测了147例肺癌及110例肺部良性疾病患者血清CYFRA-(21-1)水平,并对其临床意义进行评价。 CYFRA_(21-1) is a fragment of cytokeratin CK19, which is specifically recognized by the monoclonal antibodies BM19-21 and KS19-9. All kinds of epithelial cells have different keratins. When the epithelial cells are transformed into tumor cells, although the keratin composition remains the same, its content will increase in varying degrees. Therefore, it can be used as a tumor marker assay. This article reports the use of immunoradiometric analysis (IRMA) to detect serum CYFRA-(21-1) levels in 147 patients with lung cancer and 110 patients with benign lung disease, and to evaluate its clinical significance.