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硝基呋喃类化合物具有广谱抗菌杀虫和抗癌及杀精子等多种生物活性。呋喃类抗菌药物如呋喃(口旦)啶、呋喃唑酮和呋喃西林迄今仍被广泛应用于临床。国内外对其构效关系的研究,侧重于呋喃环2位侧链的改造,而对环上的结构修饰甚少。我们曾报道在硝基呋喃类药
Nitrofurans have broad-spectrum antibacterial insecticidal and anti-cancer and sperm and other biological activity. Furan antibacterial drugs such as furan (bin Dan) pyridine, furazolidone and nitrofurazone has so far been widely used in clinical. The research on the structure-activity relationship at home and abroad focuses on the modification of the 2-side chain of furan ring, but little modification of the structure on the ring. We have reported on nitrofurans