由催化亚单元CDK(周期素依赖激酶)和调节亚单元周期素组成的丝氨酸/苏氨酸蛋白激酶复合物家族负责真核细胞周期的初级控制。CDK本身是无活性的,而与周期素蛋白的连接对其活性及调节是必需的。现已明确CDK活性还被大量与周期素、CDK或其混合物相关的小蛋白调节。其中重要的是一些新发现的CDK抑制因子和与肿瘤生长抑制作用之间的触发关系。 The serine / threonine protein kinase complex family, consisting of the catalytic subunit CDK (cyclin-dependent kinase) and the regulatory subunit cyclin, is responsible for the primary control of the eukaryotic cell cycle. CDK itself is inactive, whereas ligation with cyclin is essential for its activity and regulation. It is now clear that CDK activity is also modulated by a large number of small proteins associated with cyclin, CDK or their mixtures. Important among these are the newly discovered triggering relationship between CDK inhibitors and tumor growth inhibition.