肿瘤的发生是一系列信号分子之间相互作用的结果。NF_κB、Akt、MAPK、p53信号途径是与肿瘤的发生、发展密切相关的信号转导途径。本文分别阐述了黄酮类物质在实验动物、人群(体内)以及不同的肿瘤细胞(体外)中对这些信号途径中的相关信号分子的调节作用,并综合了现今国内外关于黄酮类物质的抗肿瘤作用研究认为,黄酮类物质具有较明显的抗肿瘤活性,这些与肿瘤发生相关的信号转导途径可能是黄酮类物质发挥抗肿瘤作用的分子靶点。 Tumorigenesis is the result of a series of interactions between signaling molecules. NF_κB, Akt, MAPK, p53 signaling pathway is a signal transduction pathway closely related to tumorigenesis and development. In this paper, the regulatory effects of flavonoids on related signaling molecules in these signaling pathways in experimental animals, populations (in vivo) and in different tumor cells (in vitro) are described respectively, and the anti-tumor effects of flavonoids at home and abroad Role of the study that the flavonoids have more obvious antitumor activity, these signal transduction pathways associated with tumorigenesis may be flavonoids play a molecular target of anti-tumor effect.