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胰泌素具有多种生物效应,包括:刺激胰液和其中的重碳酸盐分泌、胃和十二指肠粘液分泌和肠道血流量;抑制胃泌素刺激的胃酸分泌、基础和刺激后胃泌素分泌、运动素的释放以及胃运动。上述兴奋性与抑制性效应为剂量依赖性。胰泌素并不通过酸的中介抑制胃酸分泌。这些药理作用提示应用胰泌素于诊断和治疗的可能。诊断上的应用:1.用胰泌素测定胰外分泌功能的诊断价值业已肯定。为使胰泌素-促胰酶素试验的结果具有可比性,选择合适的胰泌素制剂十分重要。作为标准
Secretin has a variety of biological effects, including: stimulating pancreatic juice and its bicarbonate secretion, gastric and duodenal mucus secretion and intestinal blood flow; inhibiting gastrin-stimulated gastric acid secretion, basal and stimulating the stomach Secretion of secretin, release of motilin, and gastric motility. The above excitatory and inhibitory effects are dose-dependent. Secretin does not inhibit gastric acid secretion through acid intermediates. These pharmacological effects suggest the potential of using secretin for diagnosis and treatment. Diagnostic applications: 1. Determination of pancreatic secretion of pancreatic exocrine function has been confirmed by the diagnostic value. It is important to choose the appropriate secretin preparation in order to make the results of the secretin-chymotrypsin test comparable. As a standard