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建立了一种快速、高效的CuI催化N-(2-溴芳基)-5-苯基-1H-吡唑-3-胺发生分子内C—N偶联反应合成苯并[4,5]咪唑并[1,2-b]吡唑衍生物的新方法.该方法以廉价的CuI/杂环烯酮缩胺为催化剂,在二甲基亚砜(DMSO)中反应只需10min,具有反应迅速、操作简便、合成效率高等优点.
A rapid and efficient CuI catalyzed intramolecular C-N coupling reaction of N- (2-bromoaryl) -5-phenyl-1H-pyrazol- Imidazo [1,2-b] pyrazole derivatives of the present invention using the inexpensive CuI / Heterocyclo-enone-amine as catalyst in dimethylsulfoxide (DMSO) for 10 min with a reaction Rapid, easy to operate, high efficiency and other advantages.