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目的：比较综合治疗与单纯放疗晚期食管癌的疗效。方法：取我院内科自１９９１年４月至１９９４年４月收治病理证实的晚期食管癌３２例，以ＤＤＰ为主的联合化疗与放疗综合治疗，并随机抽出同期单纯放疗的病例３２例作对照研究。两组病例年龄、性别、病变部位、长度、远处转移情况以及生活状态等条件均衡，具有可比性。结果：综合组ＣＲ率为４６９％，总有效率为８４４％，高于单放组ＣＲ率２１９％，总有效率５６２％（Ｐ＜０．０５）。综合组１、２年生存率分别为７１．０％和５６．０％，高于单放组２７．０％和１６．２％（Ｐ＜０．０１）。３年生存率综合组４４８％高于单放组１６２％（Ｐ＜０．０５）。结论：综合治疗优于单纯放疗，值得进一步研究。
Objective: To compare the efficacy of comprehensive treatment with radiotherapy alone for advanced esophageal cancer. METHODS: Thirty-two patients with advanced esophageal carcinoma confirmed by pathology were treated with combined DDP-based chemotherapy and radiotherapy from April 1991 to April 1994, and 32 patients with concurrent radiotherapy were randomly selected for comparison. the study. The age, sex, lesion location, length, distant metastasis, and living conditions of the two groups were balanced and comparable. Results: The overall group CR rate was 46.9%, and the total effective rate was 84.4%, which was higher than that of the single-release group. The CR rate was 21.9%, and the total effective rate was 56. 2% (P<0.05). The 1-year and 2-year survival rates in the comprehensive group were 71.0% and 56.0%, respectively, higher than those in the single-release group (27.0% and 16.2%, respectively) (P<0.01). The 3-year survival rate of the integrated group was 44.8%, which was higher than the 16.2% of the radiotherapy group (P<0.05). Conclusion:Comprehensive treatment is superior to radiotherapy alone and worthy of further study.