美国 Atlanta 一医院外科1979～1982年收治808例腹腔、软组织多种细菌感染的病人,平均年龄43.9岁,均无药物过敏史。他们随机地接受第三代头孢菌素治疗,其中149例应用羟羧氧酰胺菌素(Moxalactam),剂量10mg/kg/8h; 125例头孢氨噻(Cefotaxime)20mg/kg/8h 和141例头孢氧哌唑(Cefoperazone)20 mg/kg/12h。在三组中使用的对照药物为庆大霉素(1mg/kg/8h)加氯林可霉素(剂量分别为5mg/kg/8h、5mg/ From January 1979 to January 1980, 808 patients with intraperitoneal and soft-tissue bacterial infections in Atlanta-Atlanta Hospital were treated. The average age was 43.9 years old. There was no history of drug allergy. They were randomized to receive third-generation cephalosporins, 149 of whom received Moxalactam at a dose of 10 mg / kg / 8 h; 125 cefotaxime at 20 mg / kg / 8 h and 141 cephalosporins Cefoperazone 20 mg / kg / 12 h. Control drugs used in the three groups were gentamicin (1 mg / kg / 8 h) plus clindamycin (doses of 5 mg / kg / 8 h, 5 mg /