本试验测定了癣愈酊的急性毒性和对皮肤的刺激性与致敏性。大鼠皮肤和皮下给药LD_(50)分别为15.4ml/kg和6.05ml/kg,属低毒或无毒级水平。癣愈酊对兔完整及擦伤皮肤分别有轻微和中度的刺激性,但均明显小于对照的克霉唑癣药水引起的刺激反应。对兔皮肤有轻度致中度的致敏性。对豚鼠则高剂量组有较弱致敏性,低剂量组几无反应,说明本品致敏性较弱,临床应用适当剂量可以保证人体外用的安全性。 This test measures the acute toxicity and the irritation and allergenicity of the skin. The rats’ skin and subcutaneous administration of LD_(50) were 15.4ml/kg and 6.05ml/kg, respectively, which were of low toxicity or nontoxic level. There was slight and moderate irritation to intact and bruised skin in rabbits, but they were all significantly smaller than those induced by the control clotrimazole dip. Mild to moderate allergenicity on rabbit skin. For guinea pigs, the high-dose group had weaker allergenicity, and the low-dose group had few reactions, indicating that the product had a weaker sensitization. Clinically appropriate doses can guarantee the safety of human in vitro use.