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在大鼠阿霉素急性心肌损伤的模型上，观察了脂质体联合携载阿霉素和牛磺酸对阿霉素所致心肌损伤作用的影响。结果表明：阿霉素可引起血浆ＬＤＨ、ＣＰＫ、ＭＤＡ及心肌组织ＭＤＡ和Ｃａ２＋水平明显升高，心肌组织细胞出现广泛的变性和水肿。用牛磺酸或脂质体包裹阿霉素均可降低阿霉素对心肌毒性的作用，血浆ＬＤＨ、ＣＰＫ、ＭＤＡ及心肌ＭＤＡ和Ｃａ２＋水平比损伤组织降低５％～４６．９％（Ｐ＜０．０５）。脂质体联合携载阿霉素和牛磺酸，上述生化指标进一步降低，与正常组无明显差异，病理检查结果与上述生化指标变化一致。结果提示：脂质体联合携载阿霉素和牛磺酸具有显著减轻阿霉素心肌毒性作用。
The effects of liposomes combined with doxorubicin and taurine on doxorubicin-induced myocardial damage were observed in a rat model of doxorubicin-induced acute myocardial injury. The results showed that doxorubicin can cause plasma LDH, CPK, MDA and myocardial MDA and Ca2 + levels were significantly increased myocardial cells showed extensive degeneration and edema. Addition of doxorubicin to taurine or liposomes decreased the effect of doxorubicin on myocardial toxicity. The levels of plasma LDH, CPK, MDA and the levels of MDA and Ca2 + in myocardium decreased by 5% -46.9% (P < 0.05). Liposome combined with doxorubicin and taurine, the above biochemical index further reduced, no significant difference with the normal group, the pathological examination results consistent with the above biochemical indicators. The results suggest that liposome combined with doxorubicin and taurine can significantly reduce the myocardial toxicity of doxorubicin.