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目的 探讨胡芦巴对急性化学性肝损伤的保护作用及其机理。方法 采用四氯化碳和D 氨基半乳糖所致小鼠急性肝损伤的模型 ,染毒前不同时间、不同剂量给药对小鼠肝功能指标ALT和AST的影响 ,同时观察脂质过氧化水平。结果 胡芦巴有效地抑制CCl4 和D 氨基半乳糖所致小鼠急性肝损伤的血清ALT和AST的升高 ,并呈现良好的剂量 效应关系 ;不同治疗时间、每日给药次数对疗效有很大影响 ,每日 3次给药 ,治疗 3天以上效果较好 ;给药后 ,肝脏MDA水平降低 ,GSH Px升高 ,呈现剂量 反应关系 ,以上各指标与对照组 (不给药组 )均有显著性差异。结论 胡芦巴提取物能有效地保护小鼠急性化学性肝损伤 ,其机理可能是抑制脂质过氧化 ,增加GSH Px酶活力而发生作用
Objective To investigate the protective effect of fenugreek on acute chemical liver injury and its mechanism. Methods The model of acute liver injury induced by carbon tetrachloride and D-galactose in mice was used. The effects of different doses of erythritol before and after administration on liver function indexes of ALT and AST in mice were observed. Lipid peroxidation levels were also observed. . Results Fenugreek effectively inhibited the increase of serum ALT and AST in acute liver injury induced by CCl4 and D-galactose in mice, and showed a good dose-response relationship; different treatment time and daily administration times had very good curative effect. Large effect, 3 times a day, more effective for more than 3 days; after administration, liver MDA levels decreased, GSH Px increased, showing a dose-response relationship, the above indicators and the control group (non-administered group) are There are significant differences. Conclusion Fenugreek extract can effectively protect mice from acute chemical liver injury. The mechanism may be to inhibit lipid peroxidation and increase the activity of GSH Px enzyme.