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目的:探讨DcR3在SLE免疫紊乱过程中发生的变化及其可能作用机制。方法:选择36例SLE患者,以12例健康体检者为对照;采用ELISA法检测血清中的DcR3I、L-4和IFN-γ。结果:SLE组血清DcR3I、L-4和IFN-γ量显著高于正常对照组(P均<0.01);SLE患者中I,FN-γ/IL-4值呈两极化分布特点,以0.76为界,分为较明显的高值组(n=19,1.93±1.14)和低值组(n=170,.53±0.09)I,FN-γ/IL-4低值组的DcR3和IL-4水平比IFN-γ/IL-4高值组和正常对照组均高;DcR3与IL-4呈正相关趋势(r=0.340,P<0.05),与IFN-γ/IL-4呈负相关趋势(r=-0.332,P<0.05)。结论:SLE患者血清DcR3水平显著升高,可能通过促Th2等作用参与SLE的发生发展。
Objective: To investigate the changes of DcR3 in SLE immunodeficiency disorder and its possible mechanism. Methods: Thirty-six patients with SLE were selected and 12 healthy controls were selected as control. Serum DcR3I, L-4 and IFN-γ were detected by ELISA. Results: The levels of serum DcR3I, L-4 and IFN-γ in SLE group were significantly higher than those in normal control group (all P <0.01). The values of I and FN-γ / IL- (N = 19, 1.93 ± 1.14) and low (n = 170, .53 ± 0.09) I, FN-γ / IL- 4 levels were higher than that of IFN-γ / IL-4 high level group and normal control group. There was a positive correlation between DcR3 and IL-4 (r = 0.340, P <0.05) (r = -0.332, P <0.05). Conclusion: Serum DcR3 levels in patients with SLE are significantly increased, which may be involved in the development of SLE through the promotion of Th2 and other functions.