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目的探讨猫的初级视皮层(V1)细胞对视觉刺激空间频率的选择性是否受年龄影响。方法采用在体细胞外单细胞记录技术分别记录青、老年猫V1神经元对不同空间频率光栅刺激的调谐反应。结果数据统计分析结果显示,诱导老年猫V1神经元出现最大诱发反应幅度的平均最优刺激空间频率(optimal spatial frequency, OSF)相较于青年猫的OSF显著降低。此外,老年猫V1神经元达到半幅反应的平均高频截止空间频率(cut-off spatial frequency,CSF)也显著小于青年猫的CSF。结论该结果与在老年猴初级视皮层的研究报道一致,表明年龄相关的视皮层细胞对刺激空间频率的选择性下降可能是哺乳动物中普遍存在的现象,也可能是导致老年性视敏度下降的重要原因。
Objective To investigate whether the selectivity of spatial frequency of visual stimulation in primary visual cortex (V1) cells of cats is affected by age. Methods The extracellular single-cell recording technique was used to record the tuning responses of V1 neurons of young and old cats to different spatial frequency grating stimuli. Results The statistical analysis of the data showed that the optimal spatial frequency (OSF) for inducing maximal evoked responses in V1 neurons of aged cats was significantly lower than that of young cats. In addition, the average high-frequency cut-off spatial frequency (CSF) of half-vestibule V1 neurons of aged cats was also significantly lower than that of young cats. Conclusions This result is consistent with previous studies in the primary visual cortex of the elderly, indicating that selective reduction of age-related visual cortical cells in the spatial frequency of stimulation may be a prevalent phenomenon in mammals and may also contribute to the decline in senile visual acuity The important reason.