一、内源性鸦片样肽(Endogenous Op-ioid Peptides,EOP)及其前体蛋白 Goldstein(1973)等人用同位素标记的吗啡衍生物注射到动物体内,发现这些物质与脑内神经细胞特异地结合,因此他们推测脑内可能存在着结合吗啡的受体。经过大量的实验研究不但证明了这种受体的存在,而且还在动物脑内发现了内源性吗啡样物质。1975年,Hughes等人分离提纯了这 1. Endogenous Opioid Peptides (EOP) and Its Precursor Protein Goldstein (1973) were injected into animals with isotopically-labeled morphine derivatives and found that these substances specifically bind to neuronal cells in the brain Therefore, they hypothesized that there may be morphine binding receptors in the brain. After a large number of experimental studies not only proved the existence of this receptor, but also found in animal brain endogenous morphine-like substances. In 1975, Hughes et al. Isolated and purified this