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[目的]观察调脂方联合小剂量辛伐他汀治疗维持性血液透析脂代谢紊乱疗效。[方法]使用随机平行对照方法,将70例门诊及住院患者按随机数字表法随机分为两组,常规维持血液透析。对照组35例辛伐他汀片20mg/d,晚间顿服。治疗组35例辛伐他汀片10mg/d,晚间顿服;调脂方(葛根、玉竹、神曲各15g,当归12g,山楂15g,大黄炭10g,丹参15g,女贞子12g),1剂/d,水煎250ml,早晚温服。观测临床症状、血清胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、不良反应。治疗1疗程(3个月),判定疗效。[结果]治疗组痊愈2例,显效12例,有效17例,无效4例,总有效率88.57%;对照组痊愈1例,显效9例,有效16例,无效9例,总有效率74.29%;治疗组疗效优于对照组(P<0.05)。TC、TG、HDL-C两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05),LDL-C治疗组明显改善(P<0.05),对照组无明显变化(P>0.05)。[结论]调脂方联合小剂量辛伐他汀能有效降低血液透析患者血脂水平。
[Objective] To observe the curative effect of lipid-lowering prescription combined with low-dose simvastatin on maintenance lipid disorder of hemodialysis. [Methods] Using randomized parallel control method, 70 outpatients and inpatients were randomly divided into two groups according to random number table method, and routine hemodialysis was maintained. Control group, 35 cases of simvastatin tablets 20mg / d, Dayton evening service. Treatment group 35 cases of simvastatin tablets 10mg / d, evening Dunfu; lipid side (Pueraria, Polygonatum, Divine Comedy 15g, Angelica 12g, Hawthorn 15g, rhubarb charcoal 10g, Salvia 15g, Ligustrum lucidum 12g), 1 / d, decoction 250ml, morning and evening warm clothes. Clinical symptoms, serum cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and adverse reactions were observed. Treatment 1 course of treatment (3 months), determine the efficacy. [Results] In the treatment group, 2 cases were cured, 12 cases were markedly effective, 17 cases were effective, 4 cases were ineffective and the total effective rate was 88.57%. In the control group, 1 case was cured, 9 cases markedly effective, 16 effective and 9 ineffective. The total effective rate was 74.29% The treatment group was better than the control group (P <0.05). The levels of TC, TG and HDL-C in both groups were improved (P <0.05), the improvement in treatment group was better than that in control group (P <0.05), and LDL-C treatment group was significantly improved P> 0.05). [Conclusion] Tiaozhi prescription combined with low dose of simvastatin can effectively reduce the level of blood lipid in hemodialysis patients.